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Lion's Mane Mushroom (Hericium erinaceus) and Nerve Regeneration

By Dr. Markho Rafael


The unique flavor of the gourmet mushroom Lion's Mane (Hericium erinaceus) is often compared to either lobster or shrimp. And modern science is now discovering that not only is it a culinary delicacy but it may also possess some unique medicinal properties, with its ability to stimulate nerve and myelin regeneration. (150, 151) In the book Mycelium Running, foremost American medicinal mushroom expert Paul Stamets suggests this may make Hericium erinaceus useful in a large number of neurological conditions, from multiple sclerosis and muscular dystrophy to Alzheimer's and dementia. (134)

In the wild, Lion's Mane Mushroom (Hericium erinaceus) grows on hardwood trees, especially oak, sycamore, maple, walnut and beech. It can be found throughout the temperate areas of the world, from North America and Europe to Japan and China.

The specific medicinal compounds under scientific scrutiny are called erinacines, which are relatively small organic molecules that can pass through the blood brain barrier. Of course, passing through the blood brain barrier is essential in order to effect healing on nerve tissue or myelin sheaths. (152, 153, 154)

In Japan, there are two patents on extracts of Hericium erinaceus. The first was filed in the 1990's for a process of extraction that yields what has been named "Nerve Growth Stimulant Factor." (150, 151) The second from 2004 is for a water extract of Hericium erinaceus. It is likewise used to stimulate nerve regeneration. (155)

Although recent research on Hericium erinaceus extract has focused on its powerful effect on healing nerve tissue, in Traditional Chinese Medicine Lion's Mane Mushroom was used primarily for stomach conditions and cancers of the digestive organs.

Modern science has provided some support for this traditional use of Hericium erinaceus extract. One study conducted in 1985 reported positive results for treating atrophic gastritis. Another, published in 1995, presented findings that Hericium erinaceus helped extend the average life expectancy for patients with hepatoma. (156)

Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Never use any herb (or mushroom) except as advised by a licensed medical practitioner.

Credit to Paul Stamets for research and source material.




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